Colon Cancer Ashkenazi Jews

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Do Ashkenazi Jews have a higher than expected cancer

(1 days ago) Ashkenazi Jewish men appear to have relatively low cancer rates, which may be due to lower tobacco use. Colorectal cancer was shown to disproportionately overburden Ashkenazi Jews, who may also be at increased risk for ovarian, pancreatic and stomach cancer, and non-Hodgkin's lymphoma.

https://pubmed.ncbi.nlm.nih.gov/11411198/

Category:  Stomach Show Cancer

Participation rates of Ashkenazi Jews in a colon cancer

(1 days ago) In a recent colon cancer risk study, genetic assessment and colonoscopy were offered to virtually all of the adult Ashkenazi Jews in an urban community. The present study was designed to examine factors influencing participation and response in the initial study and to suggest strategies for improvi …

https://pubmed.ncbi.nlm.nih.gov/11940085/

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Colon Cancer - Jewish Genetic Disease

(4 days ago) The two genetic mutations associated with Ashkenazi Jewish ancestry. A mutation (I1307K) in the APC (Adenomatous Polyposis Coli) gene places one at increased risk of developing colon cancer, and some have suggested that Ashkenazi Jewish patients with a familial history of colon cancer be tested for this specific mutation.

http://mazornet.com/genetics/coloncancer.htm

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APC I1370K and Colorectal Cancer Johns Hopkins Medicine

(8 days ago) Ashkenazi Jews without a family history of colon or rectal cancers may still wish to be tested. Positive Test Result for APC I1307K. If your test is positive for the genetic mutation, experts recommend the following: If you do not already have colon cancer or polyps: You should have a routine colonoscopy every three years,

https://www.hopkinsmedicine.org/health/conditions-and-diseases/colon-cancer/apc-i1307k-and-colorectal-cancer

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Cancer Risk in Ashkenazi Jews: What to Know, What to Do

(Just Now) Ashkenazi Jews are people whose Jewish ancestors came from Central or Eastern Europe. Genetic mutations passed down from generation to generation in this group are responsible for higher-than-average rates of cancer. The risk is linked mostly to these four genes: BRCA1 and BRCA2, linked to. Breast cancer and ovarian cancer in women.

https://www.roswellpark.org/cancertalk/202001/cancer-risk-ashkenazi-jews-what-know-what-do

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APC Gene Mutation May Not Lead To Increased Colon Cancer

(8 days ago) In the absence of a significant family history of colon cancer, the study found that the APC gene alteration does not contribute to colon cancer. Dr. Andrew Godwin, a Fox Chase molecular biologist and human geneticist, looked at 264 individuals in 158 Ashkenazi Jewish families with a family history of breast and/or ovarian cancer.

https://www.cancernetwork.com/view/apc-gene-mutation-may-not-lead-increased-colon-cancer-risk-ashkenazi-jews

Category:  Breast Show Cancer

Gene Mutation Tied To Colon Cancers In Ashkenazi Jews

(6 days ago) The genetic change, or mutation, occurs in as many as 6 percent of people of Ashkenazi Jewish descent, according to preliminary studies, making it the most …

https://www.nytimes.com/1997/08/26/us/gene-mutation-tied-to-colon-cancers-in-ashkenazi-jews.html

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A636P is associated with early-onset colon cancer in

(7 days ago) The observed increased incidence of colorectal cancer in Ashkenazi Jews compared to other populations is unexplained but likely has a genetic component. The I1307K APC polymorphism/mutation is

https://www.researchgate.net/publication/10893154_A636P_is_associated_with_early-onset_colon_cancer_in_Ashkenazi_Jews

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Colon Cancer Seen Linked to Bloom Gene – The Forward

(2 days ago) Ashkenazi Jews are two to three times more likely to develop colon cancer if they carry the gene for Bloom syndrome, according to a September 2002 study by American and Israeli researchers.Dr

https://forward.com/culture/7942/colon-cancer-seen-linked-to-bloom-gene/

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The 3 cancers Jews need to worry about most - and how to

(6 days ago) Ashkenazi Jews in particular have a significantly higher risk for breast cancer: They are about three times as likely as non-Ashkenazim to carry mutations in the BRCA-1 and BRCA-2 genes that lead

https://www.jta.org/2017/04/26/united-states/the-3-cancers-jews-need-to-worry-about-most-and-how-to-reduce-the-risks

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Other Hereditary Cancers Sarnoff Center for Jewish Genetics

(4 days ago) In Ashkenazi Jews, this risk is two to three times greater. Approximately 10 percent of colorectal cancer is hereditary. Two known genetic syndromes account for a significant proportion of hereditary colorectal cancer: familial adenomatous polyposis (FAP) and Lynch syndrome, also called hereditary non-polyposis colon cancer (HNPCC).

https://www.jewishgenetics.org/cjg/Other-Hereditary-Cancers.aspx

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Colorectal Cancer Risk Factors Hereditary Colorectal

(1 days ago) Jews of Eastern European descent (Ashkenazi Jews) have one of the highest colorectal cancer risks of any ethnic group in the world. Having type 2 diabetes People with type 2 (usually non-insulin dependent) diabetes have an increased risk of colorectal cancer.

https://www.cancer.org/cancer/colon-rectal-cancer/causes-risks-prevention/risk-factors.html

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Ashkenazi Jews - Wikipedia

(4 days ago) Ashkenazi Jews (/ ˌ æ ʃ-, ɑː ʃ k ə ˈ n ɑː z i / ASH-, AHSH-kə-NAH-zee; Hebrew: יְהוּדֵי אַשְׁכְּנַז ‎, romanized: Yehudei Ashkenaz), also known as Ashkenazic Jews or by using the Hebrew plural suffix -im, Ashkenazim are a Jewish diaspora population who coalesced in the Holy Roman Empire around the end of the first millennium.. The traditional diaspora language

https://en.wikipedia.org/wiki/Ashkenazi_Jews

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Discovery of colon cancer gene sparks Jewish alarm — and

(5 days ago) Jews of Ashkenazi, or Eastern European, heritage, comprise 95 percent of the more than 5 million Jews in the United States. Colon cancer is the third most common type of cancer in the United

https://www.jta.org/1997/08/27/lifestyle/discovery-of-colon-cancer-gene-sparks-jewish-alarm-and-questions

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Genetic factors and colorectal cancer in Ashkenazi Jews

(4 days ago) In all, 215 Ashkenazi Jews with a personal history of colorectal cancer were enrolled. Clinical and family history, pathology reports, and slides were obtained and blood drawn for I1307K

https://www.researchgate.net/publication/8203280_Genetic_factors_and_colorectal_cancer_in_Ashkenazi_Jews

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A636P is associated with early-onset colon cancer in

(7 days ago) Background. Hereditary predisposition to colorectal cancer most often manifests itself as familial adenomatous polyposis from mutations of APC, or hereditary nonpolyposis colorectal cancer, resulting from mutations of MSH2, MLH1, MSH6, or other genes. Previously, we described a rare founder mutation MSH2*1906C > G in Ashkenazi Jews that was found in 8 of 1,345 individuals (0.6%) of Ashkenazi

https://www.sciencedirect.com/science/article/pii/S1072751502018082

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Ashkenazi Jewish Heritage and Genetic Risk OncoLink

(1 days ago) Ashkenazi Jews with these mutations may also have an increased risk of developing pancreatic, prostate, and skin cancer. HNPCC & APC. Two genetic mutations associated with Ashkenazi heritage are linked to gastrointestinal cancers: APC (Adenomatous Polyposis Coli) – causes an increased risk of colon cancer. This mutation is found in about 6%

https://www.oncolink.org/risk-and-prevention/genetics-family-history/ashkenazi-jewish-heritage-and-genetic-risk

Category:  Prostate,  Skin Show Cancer

Inflammatory bowel disease in Ashkenazi Jews: implications

(5 days ago) The IBD complex shows a significant increased frequency in Jews when compared to non-Jews. While there is an increased incidence of colorectal cancer (CRC) in patients with IBD, it nevertheless is important to realize that IBD likely accounts for no more than 1 …

https://edrn.nci.nih.gov/data-and-resources/publications/15516846-inflammatory-bowel-disease-in-ashkenazi

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Colorectal Cancer Causes, Risk Factors, and Prevention

(1 days ago) Lynch syndrome (hereditary non-polyposis colon cancer or HNPCC) Lynch syndrome is the most common hereditary colorectal cancer syndrome. It accounts for about 2% to 4% of all colorectal cancers. In most cases, this disorder is Jews of Eastern European descent (Ashkenazi Jews) have one of the highest colorectal 6

https://www.cancer.org/content/dam/CRC/PDF/Public/8605.00.pdf

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The I1307K APC Mutation Does Not Predispose to Colorectal

(9 days ago) An increased incidence of colorectal cancer has been observed in breast and breast-ovarian cancer syndrome families, including those of Ashke nazi origin. Recently, a germ-line missense mutation in the APC gene, I1307K, was identified that may indirectly cause colorectal cancer in Ashkenazi Jews. To determine whether the excess of colon cancer

https://cancerres.aacrjournals.org/content/canres/57/24/5480.full.pdf

Category:  Breast Show Cancer

Inherited Colorectal Cancer - WebMD

(3 days ago) Ashkenazi Jews and Colorectal Cancer Jewish people who are Ashkenazi, or of Eastern European descent, are at increased risk for colorectal cancer. This is thought to be due to a variant of the APC

https://www.webmd.com/colorectal-cancer/guide/inherited-colorectal-cancer

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The I1307K APC polymorphism in Ashkenazi Jews with

(7 days ago) Colorectal cancer is common in Ashkenazi Jews. The I1307K APC mutation occurs in 6–7% of Ashkenazi Jews and increases the risk of colorectal cancer. This study aimed to describe the clinical, pathologic and epidemiologic features of colorectal cancer in I1307K carriers to determine whether there were any features which might warrant individual screening for the mutation.

https://www.sciencedirect.com/science/article/pii/S0165460806001968

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Hereditary Cancer Syndromes Genetics and Hereditary

(2 days ago) Being or having a family member of Ashkenazi Jewish ancestry (Eastern or Central European descent) and having either breast or ovarian cancer; Having or having a family member with a rare cancer such as a sarcoma, male breast cancer, medullary thyroid cancer, or a pheochromocytoma Colon Cancer. Download Fact Sheet.

https://utswmed.org/conditions-treatments/genetics-and-hereditary-cancers/hereditary-cancer-syndromes/

Category:  Breast Show Cancer

A636P is associated with early-onset colon cancer in

(2 days ago) Previously, we described a rare founder mutation MSH2*1906C > G in Ashkenazi Jews that was found in 8 of 1,345 individuals (0.6%) of Ashkenazi descent with colorectal cancer. This study seeks to characterize the proportion of individuals of Ashkenazi heritage with very early-onset colon cancer (diagnosed at age 40 or younger) that could be

https://europepmc.org/article/MED/12595050

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The frequency of the predominant Jewish mutations in BRCA1

(9 days ago) It is presently unclear whether carriers of BRCA1 mutations have an increased risk for colorectal cancer (CRC). To gain insight into this issue, 225 unselected Ashkenazi Jewish CRC patients were

https://www.nature.com/articles/6691598

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Newly-Described Mutation Leaves Ashkenazi Jews at Higher

(Just Now) The scientists published their findings, “ A rare TP53 mutation predominant in Ashkenazi Jews confers risk of multiple cancers, ” in Cancer Research. “Germline mutations in TP53 cause a rare

https://www.genengnews.com/news/newly-described-mutation-leaves-ashkenazi-jews-at-higher-multiple-cancer-risk/

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APC I1307K Increases Risk of Transition From Polyp to

(3 days ago) colorectal cancer in the Ashkenazi Jewish population (relative risk, 1.5—1.7). However, it is unclear whether the alteration predisposes to adenomas and whether the genetic information can be used in clinical practice. To further address the pathogenic signiÞcance of I1307K, we …

https://www.gastrojournal.org/article/S0016-5085(01)50755-6/pdf

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Discovery of colon cancer gene sparks alarm, questions – J.

(9 days ago) Jews of Ashkenazi, or Eastern European, heritage comprise 95 percent of the more than 5 million Jews in the United States. Colon cancer is the third most common type of cancer in the United States and will likely kill about 55,000 men and women this year.

https://www.jweekly.com/1997/08/29/discovery-of-colon-cancer-gene-sparks-alarm-questions/

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Ashkenazi Jews weather news of another gene flaw 250

(3 days ago) Ashkenazi Jews weather news of another gene flaw 250 callers seek facts on colon cancer link Jonathan Bor THE BALTIMORE SUN Across 1,000 years of …

https://www.baltimoresun.com/news/bs-xpm-1997-09-01-1997244033-story.html

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Clinical and screening implications of the I1307K

(1 days ago) Laken et al. described a variant of the adenomatous polyposis coli (APC) gene (I1307K) in 6.1% of American Jews of European (Ashkenazi) origin and found that it occurred even more frequently (28%) in patients with Ashkenazi familial colorectal neoplasia, but it was not found in non-Jews.1 Since that report, there have been further studies that confirmed its 5–7% prevalence in asymptomatic

https://acsjournals.onlinelibrary.wiley.com/doi/full/10.1002/cncr.10529

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The I1307K polymorphism of the APC gene in colorectal

(8 days ago) Background & Aims: Colorectal cancer is one of the most frequent cancers in humans. Recently, a germline missense mutation, I1307K, was identified in the adenomatous polyposis coli (APC) gene that was suggested to increase cancer predisposition in Ashkenazi Jews. However, a second study indicated that the I1307K mutation did not contribute greatly to the risk of colon cancer in Ashkenazi

https://www.gastrojournal.org/article/S0016-5085(99)70229-5/fulltext

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Cultural Factors and Concepts of Pollution: Colorectal

(9 days ago) Ashkenazi Jews, Culture and Ethnicity 34 Burden of colorectal cancer in the Ashkenazi population 35 Colorectal Cancer Screening 36 Barriers to Colorectal Cancer Screening 36 Colorectal Cancer Screening in Ashkenazi Jews 38 Inhibitors of CRC Screening in the AJ population 38 Knowledge 39 Acceptance 41 Other Barriers 42 Summary 43

https://digitalcommons.usf.edu/cgi/viewcontent.cgi?article=1141&context=etd

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Researchers Discover New Risk Factor for Colon Cancer HHMI

(5 days ago) The results of the mouse study spurred an investigation of the role of BLM in colon cancer incidence among Ashkenazi Jews, an ethnic group in which one percent of the population carries the gene mutation that causes Bloom syndrome. A collaborative team of investigators from Memorial Sloan Kettering Cancer Center, the University of Michigan, and

https://www.hhmi.org/news/researchers-discover-new-risk-factor-colon-cancer

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Clinical and screening implications of the I1307K

(Just Now) and Israeli Ashkenazi Jews and a higher prevalence of 10–11% in those with colorectal adenoma or carcinoma (CRC).2–4 There have been further studies performed to better define the clinical implications of being a I1307K carrier. In an analysis of a large Jewish population with a variety of neoplastic disorders, Woodage et

https://acsjournals.onlinelibrary.wiley.com/doi/pdf/10.1002/cncr.10529

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APCl1307K: Introduction

(1 days ago) Ashkenazi Jews without a family history of colorectal cancer may still wish to obtain genetic counseling to learn the value of gene testing in their own unique circumstances. Genetic counseling is available, and recommended, for individuals who may have the APC I1307K mutation, and their family members.

https://www.hopkinsmedicine.org/gastroenterology_hepatology/_pdfs/small_large_intestine/APCl1307K.pdf

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Genetic factors and colorectal cancer in Ashkenazi Jews

(2 days ago) The observed increased incidence of colorectal cancer in Ashkenazi Jews compared to other populations is unexplained but likely has a genetic component. The I1307K APC polymorphism/mutation is carried by 6-8% of Ashkenazim and increases the risk of colorectal cancer 1.5-2 fold.

https://europepmc.org/article/MED/15516844

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Colon & Rectal Cancer Symptoms & Diagnosis Herbert

(9 days ago) Jewish people of Eastern European descent (Ashkenazi Jews) have a gene mutation that also puts them at a high risk for this cancer type. Age Nearly nine out of 10 people who are diagnosed with colorectal cancer are 50 or older.

https://www.cancer.columbia.edu/cancer-types-care/types/colon-and-rectal-cancer/about-colon-and-rectal-cancer

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Colon Cancer Statistics - Gastroenterologist San Antonio

(2 days ago) Jews of Eastern European descent (Ashkenazi Jews) may have a higher rate of colon cancer. The risk of death is also increased for Native Americans and Alaskan Natives; Your family history, ethnicity and race can put you at a higher risk for colon cancer. Read more about who should be screened and when.

https://www.gastroconsa.com/colon-cancer-statistics/

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Study Estimates Ashkenazi Jewish Women’s Risk of Having

(9 days ago) The New York Breast Cancer Study was started in 1996 to identify all the genes responsible for a higher risk of breast cancer among Ashkenazi Jewish women. Between 1996 and 2000, women who experienced a first diagnosis of breast cancer and who identified themselves and all four grandparents as Ashkenazi Jewish were invited to participate.

https://www.breastcancer.org/research-news/ashkenazi-jews-risk-of-other-genetic-mutations

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Why do Ashkenazi Jews have an unusually high risk of

(5 days ago) Some disease mutations unusually common in Ashkenazi Jews, who make up 90 % of the American Jewish population, include Tay-Sachs disease, some forms of breast cancer, high cholesterol and hemophilia. Four of these disorders, including Tay-Sachs disease, are in a class of diseases called lysosomal storage diseases.

http://www.jewishmag.com/161mag/jewish_disease/jewish_disease.htm

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The Founder Mutation MSH2*1906G-->C Is an Important Cause

(Just Now) Hereditary nonpolyposis colorectal cancer (HNPCC) is caused by mutations in the mismatch-repair genes. We report here the identification and characterization of a founder mutation in MSH2 in the Ashkenazi Jewish population. We identified a nucleotide substitution, MSH2*1906G- …

https://www.ncbi.nlm.nih.gov/pubmed/?term=12454801

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Colorectal Cancer, Colon, or Rectum Cancer Center

(1 days ago) Colorectal cancer is diagnosed in more than 130,000 people each year in the U.S. alone. Get in-depth colorectal cancer information here on including articles on causes, symptoms, prevention, and

https://www.webmd.com/colorectal-cancer/default.htm

Category:  Symptoms Show Cancer

What Makes Ashkenazi Jews More Susceptible to Breast

(2 days ago) The CDC reports that 1 in 40 Ashkenazi Jewish women has a BRCA gene mutation. What Makes Breast Tissue Susceptible to Cancer? A high rate of cell turnover in …

https://health.usnews.com/health-care/patient-advice/articles/2017-04-25/what-makes-ashkenazi-jews-more-susceptible-to-breast-cancer

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You Are (or Will Be) What You Eat

(4 days ago) Colorectal cancer refers to cancers found in the colon or rectum and it is the fourth most commonly detected cancer in the U.S., and with Ashkenazi Jews, it may be the highest of any ethnic group in the world. 9 There are approximately 145,600 new cases and 51,020 deaths a year. The five-year survival rate is 64% (2008-2014).

https://jewishlink.news/monthly-sections/health-link-new/44508-you-are-or-will-be-what-you-eat

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Phenotypic Characteristics Associated With the APC Gene

(6 days ago) Context The I1307K mutation of the APC gene is found in approximately 6% of the Ashkenazi Jewish population and is associated with elevated risk of colorectal cancer. The incidence of the mutation in patients with colorectal adenomas is unknown. Objectives To determine the carrier rate of the I1307K mutation in Ashkenazi Jewish patients with a history of colorectal polyps but without

https://jamanetwork.com/journals/jama/fullarticle/192997

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Johns Hopkins Gazette: September 8, 1997

(7 days ago) People of Ashkenazi Jewish heritage (typically those Jewish people whose ancestors originally lived in Eastern Europe) with at least one first degree relative (a parent, sibling or child) who has had colon cancer and who are interested in more information about …

https://pages.jh.edu/gazette/julsep97/sep0897/briefs.html

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